
个人简介:熊永伟,校聘副教授,硕士研究生导师,安徽医科大学四类引进人才。中国诱变剂学会环境表观遗传学专业委员会第一届委员会委员。主持国家科技重大专项青年人才培育项目1项、国家自然科学基金1项、安徽省自然科学基金1项和省教育厅重点项目1项,参与国家自然科学基金3项、国家重点研发计划子课题1项和安徽省杰青项目。近年来,累计发表相关学术论文20余篇,其中以第一/通讯作者在Nat Commun、Redox Biol、J Hazad Mater和Environ Pollut等国际知名期刊上发表SCI论文12篇,研究成果申请国家发明专利2项,获安徽省自然科学技术奖1项。
研究方向:生殖发育毒理学
教育经历:2020-09至 2023-06,安徽医科大学,卫生毒理学,博士
工作经历:2023-07至今,安徽医科大学,公共卫生学院,校聘副教授
代表性科研项目:
1.国家卫生健康委医药卫生科技发展中心,国家科技重大专项青年人才培育项目,2024ZD0542300,2025-05至2028-04,60万元(其中中央财政经费30万元),在研,主持;
2.国家自然科学基金委,青年科学基金项目(C类),82504459,2026-01至2028-12,30万,在研,主持;
3.安徽省科技厅,青年科学基金项目(C类),2508085QH320,2025-09至2027-08,8万,在研,主持;
4.安徽医科大学,人才引进启动基金,0301059201,2023-07至2028-07,45万元,在研,主持;
5.安徽省转化医学研究院,培育项目,2023zhyx-C08,2024-01至2026-12,8万元,在研,主持。
代表性学术论文:
1.Xiong YW(熊永伟), Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX, Wang H. Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring viaWt1 N6-methyladenosine modification.Nat Commun.2024; 15: 1353.(2023IF=14.7,中科院1区)
2.Xiong YW(熊永伟),Xu XF, Zhu HL, Cao XL, Yi SJ, Shi XT, Zhu KH, Nan Y, Zhao LL, Zhang C, Gao L, Chen YH, Xu DX, Wang H. Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress.J Hazard Mater. 2021; 401: 123438.(2020IF=10.6,中科院1区)
3.Zhang XD, Sun J, Zheng XM, Zhang J, Tan LL, Fan LL, Luo YX, Hu YF, Xu SD, Zhou H, Zhang YF, Li H, Yuan Z, Wei T, Zhu HL, Xu DX,Xiong YW(熊永伟,共同通讯作者), Wang H. Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells. Redox Biol. 2024; 76:103312.(2023IF=10.7,中科院1区)
4.Xiong YW(熊永伟), Tan LL, Zhang J, Zhu HL, Zheng XM, Chang W, Gao L, Wei T, Xu DX, Wang H. Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.Environ Pollut. 2022; 313:120112.(2021IF=10.0,中科院2区)
5.Xiong YW(熊永伟),Li DX, Ling ZJ, Tan LL, Zhang YF, Zhang J, Li H, Chang W, Zhu HL, Zhang J, Gao L, Xu DX, Yang L, Wang H. Loss of Atg5 in Sertoli cells enhances the susceptibility of cadmium-impaired testicular spermatogenesis in mice.Food Chem Toxicol.2023; 179:113967.(2022IF=4.3,中科院3区)
6.Xiong YW(熊永伟), Feng YJ, Wei T, Zhang X, Tan LL, Zhang J, Dai LM, Zhu HL, Zhou GX, Liu WB, Liu ZQ, Xu XF, Gao L, Zhang C, Wang Q, Xu DX, Wang H. miR-6769b-5p targets CCND-1 to regulate proliferation in cadmium-treated placental trophoblasts: Association with the impairment of fetal growth.Ecotoxicol Environ Saf. 2022; 230:113109.(2021IF=7.1,中科院1区)
7.Xiong YW(熊永伟), Zhu HL, Nan Y, Cao XL, Shi XT,Yi SJ, Feng YJ, Zhang C, Gao L, Chen YH, Xu DX, Wang H. Maternal cadmium exposure during late pregnancy causes fetal growth restriction via inhibiting placental progesterone synthesis.Ecotoxicol Environ Saf. 2020;187: 109879.(2019IF=4.9,中科院1区)
8.Zhang J,Xiong YW(熊永伟,共同一作), Zhu HL, Tan LL, Zhou H, Zheng XM, Zhang YF, Chang W, Xu DX, Wei T, Guan SZ, Wang H. Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition.J Hazard Mater. 2024; 476:135159.(2023IF=12.2,中科院1区)
9.Zhang J,Xiong YW(熊永伟,共同一作), Tan LL, Zheng XM, Zhang YF, Ling Q, Zhang C, Zhu HL, Chang W, Wang H. Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice.J Hazard Mater. 2023; 458:131891.(2022IF=13.6,中科院1区)
10.Zheng XM, Zhang XD, Tan LL, Zhang J, Wang TT, Ling Q, Wang H, Ouyang KW, Wang KW, Chang W, Li H, Zhu HL,Xiong YW(熊永伟,共同通讯作者),, Wang H. Sirt1 m6A modification-evoked Leydig cell senescence promotes Cd-induced testosterone decline.Ecotoxicol Environ Saf. 2024; 284: 116884.(2023IF=6.2,中科院1区)
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