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卫生毒理学系
王华
发布日期
2025-10-22
浏览人数
13819

个人简介:王华,二级教授、博士生导师,国家级青年人才,国务院政府特殊津贴获得者,美国堪萨斯大学访问学者,安徽省学术和技术带头人,现任公共卫生学院院长。从事卫生毒理学教学和科研21年,主持国家自然科学基金5项、科技部重点研发子课题2项和安徽省杰青等,以通讯作者在专业权威期刊Nat Commun、Adv Sci、Redox Biol、Environ IntCell Biol ToxicolJ Hazard Mater等发表SCI论文80余篇,获省自然科学一等奖1项和中国毒理学会首届优秀青年科技人才奖等,获国家发明专利4项。担任Food Chem Toxicol、环境与职业医学和毒理学杂志编委,以及安徽省预防医学杂志副主编。

研究方向:生殖与发育毒理学、环境暴露与亲子健康

教育经历:2011-09~2015-06安徽医科大学 儿少卫生与妇幼保健学 博士

工作经历:

2022-11~至今 安徽医科大学 公共卫生学院院长

2017-12~至今 安徽医科大学 教授和博士生导师

2016-08~2017-09美国堪萨斯大学 访问学者

2012-09~2017-12安徽医科大学 副教授和硕士生导师

2004-07~2012-09安徽医科大学 助教和讲师


代表性科研项目:

1.父代重金属暴露对子代自主运动能力的损害作用及其精子-脑轴机制研究,国自然面上项目(No:82574137),202601-202912,项目负责人;

2.胎盘雌激素减少在孕期母体镉暴露持续损害子代睾丸发育与精子发生中的作用及其机制,国自然面上项目(No: 82273664),202301-202612,项目负责人;

3.内质网PERK/ATF4信号调控的线粒体自噬在镉抑制胎盘孕酮合成与分泌中的作用,国自然面上项目(No: 81973079),202001-202312,项目负责人;

4.胎盘内质网应激在镉诱发胎儿生长受限中的作用及其分子,国自然面上项目(No: 81473016),201501-201812,项目负责人;

5.一氧化氮引起的Notch信号下调在细菌脂多糖致畸中的作用,国自然面上项目(No: 30901217),201001-20112,项目负责人;

6.关键环境不良因素影响生殖功能和子代健康的机制及早期干预策略”子课题“生殖微环境改变在不良生殖结局中的作用及分子机制”,国家重点研发计划项目子课题(No: 2022YFC27029044),202212-202511,子课题负责人;

7.“药物导致器官发育编程及疾病易感的发生机制及干预靶标”子课题“强的松所致子代发育毒性的发生机制及其毒性靶标”,国家重点研发计划项目子课题(No: 2020YFA0803900),2020.12-2025.11,子课题负责人;

8.环境毒理学,安徽省教育厅项目高校自然科学优秀创新团队(No:2023AH010035),202309-202609,项目负责人。


代表性学术论文:

1.Xiong YW, Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX*, Wang H*(通讯作者). Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification. Nat Commun 2024; 15(1):1353.(2024IF:15.7,中科院1)

2.Luo YX, Zhu HL, Huang BB, Sun CF, Zhang XX, Wang XR, Hu YF, Zhang XD, Xu SD, Zhou H, Pan R, Chang W, Yuan Z, Xiong YW, Xu XF, Zhao LL, Xu DX, Wang H*(通讯作者). Placental RTN3L-dependent ER-Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress. Adv Sci (Weinh). 2025 Jul;12(25): e2500924.(2025IF:14.1,中科院1);

3.Zhang XD, Sun J, Zheng XM, Zhang J, Tan LL, Fan LL, Luo YX, Hu YF, Xu SD, Zhou H, Zhang YF, Li H, Yuan Z, Wei T, Zhu HL, Xu DX*, Xiong YW*, Wang H*(通讯作者). Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells. Redox Biol 2024; 76:103312.(2024IF:11.9,中科院1);

4.Wang TT, Zhu HL, Ouyang KW, Wang H, Luo YX, Zheng XM, Ling Q, Wang KW, Zhang J, Chang W, Lu Q, Zhang YF, Yuan Z, Li H, Xiong YW, Wei T, Wang H*(通讯作者). Environmental cadmium inhibits testicular testosterone synthesis via Parkin-dependent MFN1 degradation. J Hazard Mater. 2024; 470:134142.(2024IF:11.3,中科院1)

5.Zhang J, Xiong YW, Tan LL, Zheng XM, Zhang YF, Ling Q, Zhang C, Zhu HL, Chang W, Wang H*(通讯作者). Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice. J Hazard Mater. 2023; 458:131891.(2023IF:12.2,中科院1);

6.Chang W, Xu SD, Liu T, Wu LL, Liu ST, Liu G, Sun J, Luo YX, Gao L, Li H, Lu Q, Yuan Z, Liu KY, Zhou H, Zhang XD, Huang YC, Xiong YW, Zhu HL, Xu DX, Wang H*(通讯作者). Risk prioritization and experimental validation of per - and polyfluoroalkyl substances (PFAS) in Chaohu Lake: Based on nontarget and target analyses. J Hazard Mater. 2025 Jul 15; 492:138179.(2025IF:11.3,中科院1).

7.Zheng XM, Zhang XD, Tan LL, Zhang J, Wang TT, Ling Q, Wang H, Ouyang KW, Wang KW, Chang W, Li H, Zhu HL, Xiong YW, Wang H*(通讯作者). Sirt1 m6A modification-evoked Leydig cell senescence promotes Cd-induced testosterone decline. Ecotoxicol Environ Saf 2024; 284:116884. (2024IF:6.1,中科院1);

8.Zhang J, Xiong YW, Zhu HL, Tan LL, Zhou H, Zheng XM, Zhang YF, Chang W, Xu DX, Wei T, Guan SZ, Wang H*(通讯作者). Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition. J Hazard Mater 2024; 476:135159. (2024IF:11.3,中科院1);

9.Li H, Wang XR, Hu YF, Xiong YW, Zhu HL, Huang YC, Wang H*(通讯作者). Advances in immunology of male reproductive toxicity induced by common environmental pollutants. Environ Int 2024; 190:108898. (2024IF:9.7,中科院1);

10.Ouyang KW, Wang TT, Wang H, Luo YX, Hu YF, Zheng XM, Ling Q, Wang KW, Xiong YW, Zhang J, Chang W, Zhang YF, Yuan Z, Li H, Gao L, Xu DX, Zhu HL, Yang L, Wang H*(通讯作者). m6A-methylated Lonp1 drives mitochondrial proteostasis stress to induce testicular pyroptosis upon environmental cadmium exposure. Sci Total Environ 2024; 931: 172938. (2024IF:8.2,中科院1)

11.Xiong YW, Feng YJ, Wei T, Zhang X, Tan LL, Zhang J, Dai LM, Zhu HL, Zhou GX, Liu WB, Liu ZQ, Xu XF, Gao L, Zhang C, Wang Q*, Xu DX*, Wang H*(共同通讯). miR-6769b-5p targets CCND-1 to regulate proliferation in cadmium-treated placental trophoblasts: Association with the impairment of fetal growth. Ecotoxicol Environ Saf 2022; 230: 113109. (2021IF7.129,中科院1区);

12.Xiong YW, Zhu HL, Nan Y, Cao XL, Shi XT, Yi SJ, Feng YJ, Zhang C, Gao L, Chen YH, Xu DX*, Wang H* (共同通讯). Maternal cadmium exposure during late pregnancy causes fetal growth restriction via inhibiting placental progesterone synthesis. Ecotoxicol Environ Saf 2020; 187:109879. (2019IF4.872,中科院1区);

13.Wang TT, Zhu HL, Ouyang KW, Wang H, Luo YX, Zheng XM, Ling Q, Wang KW, Zhang J, Chang W, Lu Q, Zhang YF, Yuan Z, Li H, Xiong YW, Wei T, Wang H*(通讯作者). Environmental cadmium inhibits testicular testosterone synthesis via Parkin-dependent MFN1 degradation. J Hazard Mater 2024; 470:134142.  (2024IF:11.3,中科院1);

14.Zhou GX, Zhu HL, Shi XT, Nan Y, Liu WB, Dai LM, Xiong YW, Yi SJ, Cao XL, Xu DX, Wang H*(通讯作者). Autophagy in Sertoli cell protects against environmental cadmium-induced germ cell apoptosis in mouse testes. Environ Pollut 2021; 270:116241. (2020IF8.071,中科院2区);

15.Li H, Hu YF, Wang XR, Ouyang KW, Wang H, Wang KW, Chang W, Zhang J, Yuan Z, Xiong YW, Zhu HL, Yang L, Wang H*(通讯作者). Suppressed testicular macrophage M1 polarization by HDAC5 enforces insensitivity to LPS-elicited blood-testis barrier damage. Food Chem Toxicol 2024; 192:114940. (2024IF:4.1,中科院2)

16.Zhang YF, Zhang S, Ling Q, Chang W, Tan LL, Zhang J, Xiong YW, Zhu HL, Bian P, Wang H*(通讯作者). Activation of lipophagy ameliorates cadmium-induced neural tube defects via reducing low density lipoprotein cholesterol levels in mouse placentas. Cell Biol Toxicol 2024; 40(1):35. (2024IF:5.3,中科院2);

17.Zhang YF, Zhu HL, Xu XF, Zhang J, Ling Q, Zhang S, Chang W, Xiong YW, Xu DX, Wang H*(通讯作者). Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction. Environ Pollut 2023; 328:121602. (2023IF:7.6,中科院2);

18.Xiong YW, Tan LL, Zhang J, Zhu HL, Zheng XM, Chang W, Gao L, Wei T, Xu DX*, Wang H*(通讯作者). Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner. Environ Pollut 2022; 313: 120112.2021IF9.988,中科院2区)。


其他学术、教学成果:

1.安徽省教学名师,2024;

2.毒理学基础安徽省教学团队负责人,2022;

发明专利:

1.胎儿生长受限的孕期母血脂质生物标志物的筛选及应用(ZL 202411788446.5),2024

2.一种雄性不育症小鼠模型的构建方法(ZL202210100169.9),2022;

3.一种父源性认知障碍动物模型的构建方法及其应用(ZL202210861165.2),2023

4.一种胎儿神经管畸形动物模型的构建方法和应用(202311439848X),2023;

5.典型环境污染物生物监测与特殊人群健康风险评估虚拟仿真实验系统软件(2022SR1462821),2022

专著:

1.编委,人卫版教材《毒理学基础》,2025;

2.副主编,科学出版社《毒理学原理与方法》研究生教材,2025;

3.共同主编,《预防医学》教材,2025;

4.副主编,人卫版《环境与健康》101教材,2025


联系方式:wanghuadev@126.com;办公电话:0551-65161168

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