
个人简介:博士研究生导师。中国毒理学会神经毒理学专业委员会委员,中国毒理学会毒理学教育专业委员会委员,中国环境诱变剂学会生物标志物专业委员会委员。研究方向:神经毒理学和衰老毒理学,结合社区老年人队列与实验室研究,解析神经退变的环境病因及机制。承担本科生《毒理学基础》和研究生《医学分子生物标志》课程教学,参编人民卫生出版社《毒理学》(第二版)、《临床毒理学》和《生活中的毒物》(主审),合肥工业大学出版社《食品毒理学》(副主编)和高等教育出版社《食品毒理学》(副主编)等教材5部。
研究方向:神经毒理学和衰老毒理学
教育经历:
2018年6月,中国科学技术大学生命科学学院神经生物学专业毕业,获博士学位,导师:周江宁;
1999年7月,安徽医科大学劳动卫生与环境卫生学专业毕业,获硕士学位,导师:孙栩;
1992年7月,安徽医科大学卫生系毕业,获预防医学学士学位。
工作经历:
2020/12至今,安徽医科大学,公共卫生学院卫生毒理学系,教授
2019/07 – 2020/07,新西兰奥塔哥大学解剖学系,访问学者(合作导师:刘萍教授)
2000/07 – 2020/12,安徽医科大学,公共卫生学院卫生毒理学系,副教授
1997/12 – 2000/07,安徽医科大学,卫生系卫生毒理学教研室,讲师
1992/07 – 1997/12,安徽医科大学,卫生系卫生毒理学教研室,助教
代表性科研项目:
1.科技创新2030—“脑科学与类脑研究”重大项目:哺乳类动物全脑介观立体定位三维图谱(编号:2022ZD0205200;起止年月:2022.8-2027.7),课题骨干。
2.合肥综合性国家科学中心大健康研究院大数据与群医学研究所科研项目:安徽省5万老年人队列建设与维护(城市)(编号:JKS2022014;起止年月:2023.6-2025.5),主持
3.国家自然科学基金面上项目:PAEs通过干扰胎盘甲状腺素转运介导神经发育毒性的作用机制(编号:81872662;起止年月:2019.1-2022.12),主持。
4.安徽省自然科学基金面上项目:胎盘联结PAEs的甲状腺素干扰与神经发育毒性作用的研究(编号1708085MH221;起止年月:2017.7-2019.6),主持。
5.国家重点研发计划2016年“重大慢性非传染性疾病防控研究”专项“阿尔茨海默?。?/span>AD)的发病机制与危险因素研究”——遗传和环境因素交互作用下神经环路的沉默与早期AD发病(项目编号:2016YFC1305900)课题:“致病基因和易感基因及发病风险预测(课题编号:2016YFC1305901;起止年月:2016.9-2020.12)”,课题骨干。
6.安徽省高校自然科学研究重点项目:功夫菊酯干扰Akt信号影响突触建立产生神经发育毒性的机制(编号:KJ2016A344;起止年月:2016.1~2017.12),主持。
7.国家自然科学基金面上项目:利用神经干细胞研究低剂量农药的神经发育毒性、作用环节及作用机制(编号:30571585;起止年月:2006.1-2008.12),主持。
8.安徽省自然科学基金项目:利用神经干细胞研究低剂量农药的神经发育毒性(编号:050430802;起止年月:2005.1~2006.12),主持。
代表性学术论文:
1 Wang Qu-Nan, Yang Fengjie,et al.,Wāng Yán*. Oral Intake of Plasticizer Di-(2-Ethylhexyl) Phthalate Disrupts Cerebellar Myelination via Thyroid Signaling in Aging Mice.Environment & Health.2026. (IF2024 = 6.3)
2 Wang Qu-Nan1, Wang Chunzhi1, Wāng Yán*. Inhalation Exposure to Tire Rubber Particle-Sourced Pollutant 6PPD-Quinone Involving Basolateral Amygdala Impairment in Male ICR Mice.Journal of Advanced Research. 2025; 10.1016/j.jare.2025.03.033. (IF2024 = 13.0)
3 Cao Shenglong, Shen Yan,et al.,Wāng Yán*, Tao Fang-Biao*,Wang Qu-Nan*. Environmental Di-(2-Ethylhexyl) Phthalate Exposure Accelerates Lipid Metabolism Disorders via the Gut-Fat Axis in Male SAMP8 Mice: Role of Gut Microbiota and Thyroid Hormone Signaling.Environment International.2025; 204: 109808. (IF2024 = 9.7)
4 Yang Xiaohan1, Cao Shenglong1,et al.,WangQu-Nan*. Di(2-Ethylhexyl) Phthalate Exposure Alters Hepatic Lipid Metabolism in Male SAMP8 Aged Mice.Journal of Applied Toxicology. 2025; 10.1002/jat.4927. (IF2024 = 2.8)
5 Jin Heyue, Wang Xianyan,et al.,Wang Qu-Nan*, Tao Fang-Biao*, Zhu Yumin*. Integrated Proteomic and Transcriptomic Landscape of Human Placenta in Small for Gestational Age Infants.iScience. 2024; 27(12), 111423.(IF2024 = 4.1)
6 Zhu Yumin1*, Zhang Yimin1,et al.,Wang Qu-Nan*, Tao Fang-Biao*. Identification and Prediction Model of Placenta-Brain Axis Genes Associated with Neurodevelopmental Delay in Moderate and Late Preterm Children.BMC Medicine. 2023; 21(1), 326.(IF2023 = 7.1)
7 Jin Heyue, Zhang Yimin,et al.,Wang Qu-Nan*, Tan Fang-Biao*, Zhu Yumin*. Identification of Novel Cell-Free RNAs in Maternal Plasma as Preterm Biomarkers in Combination with Placental RNA Profiles.Journal of Translational Medicine.2023; 21(1), 256.(IF2023 = 6.1)
8 Ren Wenqiang, Liu Nuo,et al., Wāng Yán*,WangQu-Nan*. Subchronic Exposure to Di-(2-Ethylhexyl) Phthalate (DEHP) Elicits Blood-Brain Barrier Dysfunction and Neuroinflammation in Male C57BL/6J Mice.Toxicology. 2023; 499: 153650. (IF2023 = 4.8)
9 Bao Chao1, Lv Jia1,et al., Tao Fang-Biao*,Wang Qu-Nan*. Chronic Inflammation as a Potential Mediator Between Phthalate Exposure and Depressive Symptoms.Ecotoxicology and Environmental Safety. 2022; 233: 113313.(IF2022 = 6.8)
10 Lv Jia1, Li Yanling1,et al., Huang Yichao*,Wang Qu-Nan*. Maternal Exposure to Bis(2-Ethylhexyl) Phthalate During the Thyroid Hormone-Dependent Stage Induces Persistent Emotional and Cognitive Impairment in Middle-Aged Offspring Mice.Food and Chemical Toxicology. 2022; 163: 112967.(IF2022 = 4.3)
11 Lv Jia1, Li Yanling1,et al.,Wang Qu-Nan*.Increased Depression Risk for Elderly Women with High Blood Levels of Strontium and Barium.Environmental Chemistry Letters. 2021; 19(2): 1787-1796.(IF2021 = 13.6)
12 Cheng Beijing1, Xu Peiru1, Wei Rong1,et al.,Wang Qu-Nan*,Yang Lin-Sheng*. Levels and Determinants of Urinary Phthalate Metabolites in Chinese Community-Dwelling Older Adults.Science of the Total Environment. 2021; 762: 144173.(IF2021 = 10.8)
13 Li Yanling1, Lv Jia1,et al.,Wang Qu-Nan*.The Levels of Phthalate Exposure and Associations with Obesity in an Elderly Population in China.Ecotoxicology and Environmental Safety. 2020; 201: 110749.(IF2020 = 6.3)
14 Du Zhiping, Feng Shun,et al., Liu Ping*,Wang Qu-Nan*.Di-(2-Ethylhexyl) Phthalate Inhibits Expression and Internalization of Transthyretin in Human Placental Trophoblastic Cells.Toxicology and Applied Pharmacology. 2020; 394: 114960.(IF2020 = 4.2)
其他学术、教学成果:
1.《食品毒理学》(工业和信息化部“十四五”规划教材),高等教育出版社,2024,副主编
2.《生活中的毒物》,人民卫生出版社,2020,编委,主审
3.《毒理学》(第二版),人民卫生出版社,2017,编委
4.《食品毒理学》,合肥工业大学出版社,2017,副主编
5.《临床毒理学》,人民卫生出版社,2016,编委
联系方式:wqn@ahmu.edu.cn;办公电话0551-65161170