
个人简介:赵素娟,中共党员,博士,教授,就职于安徽医科大学公共卫生学院职业卫生与环境卫生学系。近年来,主持国家自然科学基金2项,安徽省自然科学基金2项,省高校优秀人才支持计划1项,先后参加多项国家自然科学基金项目和省部级科研项目,发表多篇SCI学术论文。
研究方向:主要研究方向为水体污染和生态毒理学,关注微囊藻毒素的生态毒理学研究,特别是蓝藻水华对水生生物作用的分子机制、危险评价、健康危害及生态毒理学效应。
教育经历:中国科学院大学 博士
工作经历:
2013.7至今 安徽医科大学
2019-2020 南开大学访学
代表性科研项目:
1.安徽省自然科学基金面上项目,微囊藻毒素MCLR暴露通过胎盘-脑轴色氨酸代谢通路引起子代神经发育异常变化及作用机制,2408085MC074,主持;
2.国家自然科学基金面上项目,31971521,父代微囊藻毒素暴露致子代斑马鱼神经发育损害的表观遗传机制,主持;
3.安徽省高校优秀人才支持计划,gxyq2019011,父代斑马鱼微囊藻毒素暴露通过精子表观遗传改变致子代神经发育损伤的机制研究,主持;
4.国家自然科学基金青年项目,31400455,内质网应激和线粒体通路交联介导微囊藻毒素致斑马鱼雄性生殖细胞凋亡中的作用,主持;
5.安徽省自然科学基金青年项目,1408085QH160,GABA和谷氨酸神经递质在微囊藻毒素诱发斑马鱼神经毒性中的分子作用机制,主持;
代表性学术论文:
(1)Zhao, S.J.#; Sun, Y.M.; Duan, J.Y.; Zhang, T.X.; Xiao, Y.C.; Zhu, Y.M.; Jia, Y.B.; Zhong, W.J.; Zhu, L.Y.*, Impacts of gestational F 53B exposure on fetal neurodevelopment: Insights from placental and thyroid hormone disruption. Environment & Health 2024.
(2)Xiao, Y.C. #; Hu, L.W. #; Duan, J.Y.; Che, H.H.; Wang, W.X.; Yuan, Y.; Xu, J.Y.; Chen, D.J.; Zhao, S.J.*, Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryo. Environ Pollut 2024, 1:352:124022.
(3)Duan, J.Y.#; Xiao, Y.C.#; Wang, W.X.; Yuan, Y.; Ju, W.; Wu, B.C.; Hu, L.W.; Tuo, X.; Jiang, M.M.; Zhao, S.J.*,Synergistic reproductive toxicity of microcystin-LR and polystyrene micro/ nano-plastics in male zebrafish. Ecotoxicology and Environmental Safety 2025,299,118377.
(4)Xu, J.Y.#; Zhang, W.Y.; Zhong, S.Z.; Xie, X.X.; Che, H.M.; Si, W.R.; Tuo, X.; Xu, D.X.; Zhao, S.J.*, Microcystin-leucine-arginine affects brain gene expression programs and behaviors of offspring through paternal epigenetic information. Sci Total Environ 2023, 857:159032.
(5)Si, W. #; Zhao, M. #; Che, H.; Wu, Z.; Xiao, Y.; Xie, X.; Duan, J.; Shen, T.; Xu, D.; Zhao, S. J.*, Microcystin-LR induced transgenerational effects of thyroid disruption in zebra?sh offspring by endoplasmic reticulum stress-mediated thyroglobulin accumulation and apoptosis. Environ Pollut 2023, 322:121117.
(6)Zhao, S.J. #; Xu, J.Y.; Zhang, W. Y.; Yan, W.; Li, G.Y. *, Paternal exposure to microcystin-LR triggers developmental neurotoxicity in zebrafish offspring via an epigenetic mechanism involving MAPK pathway. Sci Total Environ 2021, 792:148437.
(7)Zhao, S.J. #; Yuan, C.Y.; Tuo, X.; Zhou, C.F.; Zhao, Q.H.; Shen, T. *, MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells. Chemosphere 2021, 263:127868.
(8)Wu, Z.W. #; Wang, F.; Hu, L.W.; Zhang, J.R.; Chen, D.J.; Zhao, S.J. *, Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells. Ecotoxicol Environ Saf 2021, 221:112438.
(9)Zhao, S.J. #; Zhong, S.Z.; Wang, F.; Wang, H.H.; Xu, D.X. *; Li, G.Y. *, Microcystin-LR exposure decreased the fetal weight of mice by disturbance of placental development and ROS-mediated endoplasmic reticulum stress in the placenta. Environ Pollut 2020, 256:113362.
(10)Zhong, S.Z. #; Liu, Y.; Wang, F.; Wu, Z.W.; Zhao, S.J. *, Microcystin-LR induced oxidative stress, inflammation, and apoptosis in alveolar type II epithelial cells of ICR mice. Toxicon 2020, 174, 19-25.
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